In Vitro Enzyme Assays for JmjC-Domain-Containing Lysine Histone Demethylases (JmjC-KDMs)
نویسندگان
چکیده
منابع مشابه
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
Covalent modifications of histones, such as acetylation and methylation, play important roles in the regulation of gene expression. Histone lysine methylation has been implicated in both gene activation and repression, depending on the specific lysine (K) residue that becomes methylated and the state of methylation (mono-, di-, or trimethylation). Methylation on K4, K9, and K36 of histone H3 ha...
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ژورنال
عنوان ژورنال: Current Protocols in Pharmacology
سال: 2018
ISSN: 1934-8282
DOI: 10.1002/cpph.34